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Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.

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2024

Developmental toxicity of emerging perfluoroalkyl ether carboxylic acids of varying chain length: PFMOAA, PFO4DA and PFO5DoA
(PRESENTATION) [Presented : Jun 26, 2022]

Multiple per- and polyfluoroalkyl ether acids have recently been detected in drinking water and/or human serum, but there is a paucity of data on potential toxicity despite known exposure.  Perfluoro-2-methoxyacetic acid (PFMOAA) is a short chain ether carboxylate (3 carbons...

Effects-based bioassay screening approaches applied to residential tapwater to inform consumer point-of-use decisions
(PRESENTATION) [Presented : Nov 15, 2023]

Effects-based bioassays are expeditious and economic non-targeted chemical analysis tools frequently used in preliminary stages of water quality monitoring efforts, or as part of effects-directed analysis. Using in vitro effects-based methods, we previously detected biological ac...

Deiodinase metabolism of thyroid hormones as measured by LC-MS/MS is altered by exposure to iopanoic acid in a rodent model
(PRESENTATION) [Presented : Mar 12, 2024]

Thyroid hormones (TH) are highly iodinated molecules that regulate many aspects of mammalian physiology and are essential for normal growth and development. Deiodinases (DIO) are a family of three metabolizing enzymes (DIO1, DIO2, DIO3) by activating or deactivating TH action. Th...

Geographic and demographic variability in serum PFAS concentrations for pregnant women in the United States
(JOURNAL) [Published : Jan 25, 2023]

BACKGROUND. While major pathways of human PFAS exposure are thought to be drinking water and diet, other pathways and sources have also been shown to contribute to a person’s cumulative exposure. However, the degree of contribution of these other sources to PFAS body burdens is s...

Adverse effects in traditional and alternative toxicity tests
(JOURNAL) [Published : Mar 01, 2024]

Chemical safety assessment begins with defining the lowest level of chemical that alters one or more measured endpoints. This critical effect level, along with factors to account for uncertainty, is used to derive limits for human exposure. In the absence of data regarding the sp...

Maternal, fetal, and neonatal toxicity of the long-chain, multi-ether PFAS PFO5DoA in the Sprague-Dawley rat
(PRESENTATION) [Presented : Mar 13, 2024]

Abstract reduced to fit RAPID character limits - full abstract attached Background and Purpose Recent human and ecological biomonitoring studies in the US and China have identified novel perfluoroalkyl carboxylic acids with ether linkages between each fluorinated carbon in a homo...

Proteome profiling of rat brain cerebellum during the early postnatal brain development
(PRESENTATION) [Presented : Mar 12, 2024]

Background and Purpose: During the sensitive perinatal period, environmental stressors are a threat to brain development. We applied proteomics to investigate the protein changes occurring during the early postnatal rat cerebellum development. Methods: High-resolution mass spect...

Dose addition-based approaches accurately predict maternal and neonatal effects in Sprague-Dawley rats from three different PFAS mixtures studies
(PRESENTATION) [Presented : Mar 22, 2023]

Due to the pervasive detection of multiple PFAS in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches.  However, the literature is lacking mammalian in vivo studies that test additivity by co...

Early Gestational Ozone Exposure Impairs Lung Vascular and Alveolar Development in Peri-adolescent Female Rats: Potential Linkage to Later Life Lung Disease
(PRESENTATION) [Presented : Feb 20, 2024]

RATIONALE  Air pollution exposure in pregnancy may affect fetal growth, and fetal growth restriction (FGR) is associated with lung impairment that can persist into adulthood. Associated diseases include asthma, pulmonary hypertension (PH), and chronic obstructive p...

Pathway analysis of developmental rat cerebellar and cortical proteomes following perinatal agonism of GABA-gated chloride channels
(PRESENTATION) [Presented : Mar 13, 2024]

The period of neurodevelopment is vulnerable to various insults, including those produced by environmental compounds. We have previously observed behavioral alterations (uncoordinated hindlimb gait, decreased startle response, altered motor activity ontogeny) following perinatal ...

Neurophysiological assessment of peripheral nerve, somatosensory, and brainstem auditory function after perinatal exposure to emamectin in Long Evan rats
(PRESENTATION) [Presented : Mar 12, 2024]

Background: We have previously observed altered ontogeny of locomotor activity and uncoordinated hindlimb gait and decreased startle response in adult animals following perinatal exposure to emamectin benzoate (EB), which acts as a positive allosteric modulator for GABA-gated chl...

Use of the Fischer rat thyroid follicular cell (FRTL-5) iodide uptake assay as a secondary screen of per- and polyfluoroalkyl substances (PFAS) previously identified as potential human sodium-iodide symporter (hNIS) inhibitors.
(PRESENTATION) [Presented : Mar 12, 2024]

Based on the increasing number of PFAS in the environment that have the potential to disrupt thyroid hormone function and developmental health outcomes, the U.S. EPA selected a representative set of PFAS for thyroid specific high throughput screening (HTS) targeting synthesis, tr...

Characterization of signaling pathways in in vitro developmental neurotoxicity battery
(PRESENTATION) [Presented : Mar 14, 2024]

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Prenatal Cadmium or High Fructose Exposure Alters the Physiological Stress Response to High Temperature in a Sex-Dependent Manner
(PRESENTATION) [Presented : Mar 14, 2024]

Background and Purpose: Populations living near Superfund sites are exposed to heavy metals as a byproduct of anthropogenic waste. Individuals dwelling near Superfund sites may lack accessibility to healthy dietary choices and may consume diets high in fructose. The combination o...

A Novel Histological Method to Detect Abnormal Thyroid Hormone Action in the Developing Rat Brain
(PRESENTATION) [Presented : Mar 13, 2024]

Assaying for thyroid interference is of increasing importance in standardized developmental and reproductive toxicity studies. While serum T4 quantification is an endpoint assessed in developing rats, it is unclear how this measure may correlate to adverse neurodevelopmental outc...

Exploring maternal and developmental toxicity of PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics
(PRESENTATION) [Presented : Mar 12, 2024]

Sprague-Dawley rat dams were exposed via oral gavage from GD18-22 to PFO4DA or PFO5DoA across a series of doses ranging from 0.1 to 62.5 mg/kg/d. Fetal livers and maternal livers and serum were collected on GD22 and hepatic transcriptomics in both dam and offspring and serum meta...

Evaluation of Oral Anatoxin-a Health Effects in Mice
(PRESENTATION) [Presented : Mar 14, 2024]

Abstract for Harmful Algal Blooms Session at SOT 2024 Anatoxins are small, water-soluble molecules produced by cyanobacteria in fresh and marine waters globally. They are known to cause prolonged depolarization at the neuromuscular junctions leading to generalized paralysis and c...

Anatoxin-a: formulation and stability in support of rodent studies
(PRESENTATION) [Presented : Mar 13, 2024]

Anatoxin-a (ATX) is a cyanobacterial neurotoxin produced in freshwater lakes, streams, and reservoirs both in planktonic and benthic blooms. It is a potent and irreversible nicotinic acetylcholine receptor (nAChR) agonist that causes central and peripheral effects while it is the...

In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models
(PRESENTATION) [Presented : Mar 14, 2024]

Background and Purpose An extensive battery of assays has been developed for assessing developmental neurotoxicity (DNT), with the aim of replacing traditional in vivo guideline studies for risk assessment. These in vitro assays hold many advantages over costly, lengthy, in vivo ...

A cheminformatics workflow to select representative TSCA chemicals for New Approach Methodology (NAM) screening
(PRESENTATION) [Presented : Mar 14, 2024]

Background: The Toxic Substances Control Act (TSCA) requires the US Environmental Protection Agency (EPA) to evaluate the hazard and exposure to new and existing chemicals. New chemical notifications are typically data poor and EPA?s Office of Pollution Prevention and Toxics (OPP...

A systematic comparison of read-across within REACH registration dossiers with Generalised Read-Across (GenRA)
(PRESENTATION) [Presented : Mar 14, 2024]

Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar source analogues. Read-across acceptance remains an issue, mainly due to the difficulties of addressing residual uncertainties and because read-across is stil...

Potassium jarosite seeding of soils decreases Pb and As bioaccessibility: Concurrent remediation
(PRESENTATION) [Presented : Nov 01, 2023]

Lead (Pb) and arsenic (As) contamination of soils is widespread in the United States and is an important source of exposure in young children. Early life exposure to metal(loid) contaminants has serious and long-lasting effects on health, making mitigation a critical public healt...

Jarosite-based remediation of Pb/As contaminated soils: Assessing the potential for grass growth and long-term efficacy (2023 SSSA conference)
(PRESENTATION) [Presented : Nov 01, 2023]

Lead (Pb) is a pervasive environmental contaminant commonly sourced from anthropogenic activities such as smelting, lead-based paint, and exhausted leaded gasoline.  Soils in residential neighborhoods are of particular concern as soil Pb may cause significant adverse health ...

Towards an Animal Component-Free System for High Throughput Phenotypic Profiling of Human Neural Progenitor Cells
(PRESENTATION) [Presented : Mar 14, 2024]

Background and Purpose       High Throughput Phenotypic Profiling (HTPP) is an in vitro screening method that combines cell viability and “Cell Painting” assays to derive chemical-specific phenotypic profiles and phenotype altering concentrations (PACs)...

Potential Collaboration with Region 2 and Community Engaged Research Collaborative for Learning and Excellence: Community level model to assess cumulative impacts and effectiveness of multi-media interventions in improving public health and mitigating the effects of climate change in addressing environmental justice
(PRESENTATION) [Presented : Jun 28, 2023]

Underground Storage Tanks and EJ Presentation for Region 2 and Community Engaged Research Collaborative for Learning and Excellence. Community level model to assess cumulative impacts and effectiveness of multi-media interventions in improving public health and mitigating the e...